Predictive Disease Risk Modeling at 23andMe with Subarna Sinha

Today we're joined by Subarna Sinha, Machine Learning Engineering Leader at 23andMe. 23andMe handles a massive amount of genomic data every year from its core ancestry business but also uses that data for disease prediction, which is the core use case we discuss in our conversation. Subarna talks us through an initial use case of creating an evaluation of polygenic scores, and how that led them to build an ML pipeline and platform. We talk through the tools and tech stack used for the operationalization of their platform, the use of synthetic data, the internal pushback that came along with the changes that were being made, and what's next for her team and the platform.